There is insufficient data on the use of a combination of primobolan acetate or both drugs alone in pregnant women. Piperacillin and tazobactam cross the placental barrier. Pregnant women drug can be administered only in cases where the expected benefit to the mother outweighs the potential risk to the fetus.
Piperacillin is secreted in low concentrations in breast milk;selection tazobactam has not been studied in milk.If necessary, use during lactation is necessary at the time of treatment stop breastfeeding.
Dosing and Administration
Slow intravenous bolus over no less than 3-5 minutes or infusion over 20-30 minutes.
The duration of treatment is determined by the severity of infection and dynamics of clinical and bacteriological parameters.
Adults and children over 12 years of age with normal renal function,
the recommended dose of the drug, which primobolan acetate is administered every 8 hours, 4.5 g (4 g piperacillin / tazobactam 0.5 g).
The total daily dose depends on the severity and localization of the infection and can vary from 2.25 g (2 g piperacillin / tazobactam 0.25 g) and 4.5 g (4 g piperacillin / tazobactam 0.5 g) preparation administered every 6 or 8 hours.
Children aged 2 to 12 years old.
Patients children with normal renal function and body weight less than 50 kg with a fever, occurred against the backdrop of neutropenia, the dose is 90 mg (80 mg piperacillin / 10 mg tazobactam) per kilogram . body, which is administered every 6 hours in combination with an appropriate dose of an aminoglycoside
children weighing more than 50 kg the dose corresponds to an adult, and enter it in combination with an aminoglycoside. If intraabdominalnoy infection: in children weighing up to 40 kg and normal renal function the recommended dose of 112.5 mg / kg of the drug (100 mg piperacillin / 12.5 mg tazobactam) every 8 hours. For children weighing more than 40 kg and normal renal function administered the same dose as adults, that is 4.5 g of the preparation (4 g piperacillin / tazobactam 0.5 g) every 8 hours. Treatment primobolan acetate should be for at least five days and at most 14 days, given that the administration is continued for at least another 48 hours after the disappearance of clinical signs of infection. renal impairment patients with renal impairment or patients who are on hemodialysis, the dose and frequency of administration should be adjusted according to the degree of renal impairment. The recommended dose for adults and children in patients with renal failure.