Hypersensitivity to alendronic acid and alfacalcidol and other ingredients; conditions leading down the esophagus advancing food (including esophageal stricture or achalasia); the inability of the patient to stand or sit upright for at least 30 minutes; hypocalcemia; hypercalcemia; Burnett syndrome and / or milk-alkali syndrome (plasma calcium concentration of more , more calcium phosphate primobolan steroid, violation of severe renal failure (creatinine clearance ; patients on hemodialysi; hyperphosphatemia (except hyperphosphatemia with hypoparathyroidism); gipermagniemiya; deficit sucrase / isomaltase, fructose intolerance, glucose-galactose malabsorption; childhood; during pregnancy and breastfeeding.
gastrointestinal disorders in the acute phase, including dysphagia, esophagitis, gastritis, duodenitis, gastric ulcer and duodenal ulcers, hypoparathyroidism, hypovitaminosis D,. Calcium malabsorption, nephrolithiasis, atherosclerosis, impaired renal function (creatinine clearance greater than 35 mL / min), chronic heart failure, in patients with an increased risk of hypercalcaemia, including leukemia, lymphoma, sarcoidosis, pulmonary tuberculosis (active form).
Pregnancy and lactation
Due to insufficient data on the use of alendronic acid and / or at risk of an overdose of the drug Alfacalcidol Tevabon contraindicated in pregnancy and during primobolan steroid breastfeeding.
Dosing and Administration
The drug Tevabon consists of two dosage forms:. Tablet of alendronate and alfacalcidol capsules
should strictly observe the recommendations for the use and dosage To ensure proper absorption and reduce the risk of adverse reactions. Alendronic acid, Inside, 1 tablet (70 mg) 1 times a week, a glass of water, at least 30 minutes before the first food, beverage or other medicaments. Wash down only ordinary water, as other beverages (including mineral water), food and certain drugs may decrease the bioavailability of alendronate. Tablets should not be chewed or dissolve. After taking the pill the patient must remain upright (sitting or standing) for at least 30 minutes. . You can not take the pill at bedtime or before the morning rise from the bed Elderly patients No dose adjustment is required. Renal impairment When QC more than 35 ppm / min dose adjustment is required. Alfacalcidol Inside: 1 capsule (1 mg), 1 per day in the evening daily. The capsules should be swallowed whole, drinking plenty of fluids. The drug Tevabon designed for prolonged use.
Side effects classified in accordance with the following frequency: very often – at least 10%; often – at least 1% but less than 10%; infrequently – at least 0.1% but less than 1%; rare – less than 0.01% but less than 0.1%; very rarely – less than 0.01%, including isolated cases. In the application of alendronate From the digestive system: often – abdominal pain, indigestion, acid regurgitation, diarrhea, dysphagia, flatulence, gastritis, gastric ulcer, ulceration of the esophageal mucosa; infrequently – nausea, vomiting, constipation, gastritis, esophagitis, esophageal mucosal erosion, melena, rarely – esophageal stricture, ulceration of the mucous membrane of the oropharynx, esophagus perforation, bleeding from the upper gastrointestinal (connection with taking alendronate is not installed). From the musculoskeletal system:often – pain in the bones, muscles, joints, muscle cramps; rarely – osteonecrosis of the jaw, mainly in cancer patients treated with , however, such cases were noted in patients undergoing therapy for osteoporosis; unknown frequency – stress fracture of the proximal femur associated or not associated with an injury. On the part of metabolism: rarely – symptomatic hypocalcemia, usually associated with predisposing conditions, hypophosphatemia. On the part of the central nervous system primobolan steroid: common – headache. From the sensory organs: rarely – uveitis, scleritis, episcleritis. Allergic reactions: seldom – rash, pruritus, erythema; rarely – rash associated with photosensitivity, urticaria, angioedema, very rarely – severe skin reactions, including multiforme exudative erythema (Stevens-Johnson syndrome) and toxic epidermal necrolysis (Lyell’s syndrome). Other: rarely – transient symptoms similar to symptoms in the acute phase of the disease (myalgia, malaise and fever), typically in . early treatment When applying alfacalcidol From a metabolism: seldom – hypercalcemia; very rarely – a slight increase in the plasma concentration of high density lipoproteins. In patients with severe renal impairment may develop hyperphosphatemia, heterotopic calcification in the cornea and blood vessels. From the digestive system: rarely – anorexia, vomiting, heartburn, abdominal pain, nausea, dry mouth, discomfort in the epigastric region, constipation diarrhea; rarely – a slight increase in activity of “liver” enzymes in the plasma (alanine aminotransferase, aspartamaminotransferaza). From the musculoskeletal system: rarely . – moderate pain in the muscles, bones, joints Allergic reactions: seldom – skin rash, itching; very rarely -. anaphylactic shock, in communication with peanut butter in connection with the multi-directional influence of alendronate and alfacalcidol on serum calcium concentrations, the combination of these drugs allows to avoid sharp fluctuations in the calcium concentration in the serum.